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KMID : 0352119950110020175
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Journal of Kyung Hee University
1995 Volume.11 No. 2 p.175 ~ p.180
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A Study on Protein error of pH Indicator in Alkaline urine
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Abstract
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Screening test for proteinuria by using reagent strip (RS) has been a important indicator of renal disease. The principle of RS test to detect proteinuria is based on pH change in the presence of protein, mostly albumin. Akaline urine has been
reported
to affect RS test for proteinuria. The purpose of this study is to investigate the false positive rate of RS test for proteinuria by comparing with sulfosalicylic acid (SSA) test.
Two hundreds of alkaline urine specimens were examined by using RS and SSA tests, simultaneously. As a negative control, 200 urine specimens with normal pH also evaluated. For RS test, Clinitek 200 (Ames, USA) automatic machine were used.
Of 200 alkaline urine specimens, 67(33.5%) were positive in RS test, while 51 (25.5%) were positive in SSA test. Of 200 urine specimens with normal pH, 37 (18.5%) showed positive reaction in RS test, whereas 35 (17.5%) showed positive reaction in
SAA
test.
In conclusion, alkaline urine causes false positive reaction for proteinuria in RS test. Therefore, in the cases of alkaline urine specimens, SSA test is recommended for exact detection of proteinuria.
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